Bioterrorism

Profiles for Health Care Workers (Fact Sheets) - "B" Agents

  • Health Care Providers: If you suspect a patient has been exposed to a biological or chemical agent please call the Office of Infectious Disease Services at (602) 364-4562
    On-call staff are available 24 hours a day, 7 days a week.

Brucellosis | Cholera | (Epsilon Toxin of) Clostridium Perfringens | Cryptosporidiosis | Eastern Equine Encephalitis
Escherichia Coli O157:H7 | Glanders | Melioidosis | Psittacosis | Q Fever | Ricin | Salmonellosis
Shigellosis | Staphyloccal Enterotoxin B | Tricothecene Mycotoxins (T-2 Mycotoxins)
Typhus Fever | Venezuelan Equine Encephalitis | Western Equine Encephalitis

Psittacosis

Causative Agent:
Psittacosis is an avian illness that can also cause disease in humans. It is caused by the rickettsia-like bacteria Chlamydophila psittaci (formerly Chlamydia psittaci).

Routes of Exposure:
Humans are primarily exposed to psittacosis through inhalation of dried secretions from infected birds.

Infective Dose & Infectivity:
The infective dose is unknown and all people are considered susceptible, though older adults may be more severely affected.

Incubation Period:
The incubation period ranges from 1 to 4 weeks.

Clinical Effects:
An acute, generalized chlamydial disease with variable clinical presentations; fever, headache, rash, myalgia, chills, and upper or lower respiratory tract disease are common. Respiratory symptoms are often disproportionately mild when compared with the extensive pneumonia demonstrable by x-ray. Cough is initially absent or nonproductive; when present, sputum is mucopurulent and scant. Pleuritic chest pain and splenomegaly occur infrequently; the pulse may be slow in relation to temperature. Encephalitis, myocarditis, and thrombophlebitis are occasional complications; relapses may occur. Although usually mild or moderate in character, human disease can be severe.

Lethality:
The mortality rate for untreated psittacosis ranges from 15-20%. However, with appropriate treatment, the mortality rate drops to less than 1%.

Transmissibility:
Infection with C. psittaci generally occurs when a person inhales the organism, which has been aerosolized from dried feces or respiratory secretions of infected birds. Psittacosis can also be acquired through mouth-to-beak contact and the handling of infected birds’ plumage and tissues. Rare person-to-person transmission has been reported to occur during the acute illness with paroxysmal coughing. However, Chlamydophila pneumoniae, rather than C. psittaci, organisms may have caused these cases.

Primary contaminations & Methods of Dissemination:
As a bioterrorism weapon, psittacosis would most likely be delivered via aerosolization.

Secondary Contamination & Persistence of organism:
Secondary cases cannot be proven and are extremely rare. Diseased as well as seemingly healthy birds may shed the agent intermittently, and sometimes continuously, for weeks or months.

Decontamination & Isolation:

  • Patients – Standard precautions should be practiced. Specific isolation procedures are not indicated.
  • Equipment, clothing & other objects – 0.5% hypochlorite solution (one part household bleach and 9 parts water = 0.5% solution) is effective for environmental decontamination.

Laboratory testing:
Most diagnoses are established by using microimmunofluorescence (MIF) to test for antibodies to C. psittaci in paired sera. Since there is some antibody cross-reactivity between chlamydial species, polymerase chain reaction (PCR) assays can be used to further distinguish C. psittaci infection from other chlamydial species.

Therapeutic Treatment:
Tetracyclines are the drugs of choice. Most patients respond to oral therapy, but for severely ill patients doxycycline can be administered intravenously. Though remission of symptoms usually is evident within 48-72 hours, relapse can occur. Therefore, treatment must continue for at least 10-14 days after fever abates. Erythromycin is an alternative when a tetracycline is contraindicated.

Prophylactic Treatment:
There is no vaccine available for human use. Post-exposure chemoprophylaxis is not indicated.

Differential Diagnosis:
The differential diagnoses should include illnesses with fever and respiratory symptoms including illnesses such as Q fever, mycoplasma, legionnaires’ disease, and influenza.

References:

  • Chin J. Control of Communicable Diseases Manual, Seventeenth Edition, American Public Health Association; 2000.
  • National Association of State Public Health Veterinarians. Compendium of Measures to Control Chlamydophila psittaci (formerly Chlamydia psittaci) Infection Among Humans (Psittacosis) and Pet Birds, The American Veterinary Medical Association; 2004


Find the PDF version of this Fact Sheet in the Zebra Manual.